Fine-tuning patient-derived xenograft models for precision medicine approaches in leukemia

Synthetic human leukemia models: towards precision medicine

Patient-derived xenograft models for oncology drug discovery

The success of targeted therapies for cancer patients rests on three major components: the right target(s), the right drug and drug combination, and the right patient population. Although much progress has been made in understanding the mechanism of disease and in refi ning pharmaceutical properties of therapeutic agents, the attrition rates between target discovery and drug marketing approval ...

Precision spraying: using fine tuning and electronics

In the spray application process the key factor is to know the location and volume of the target. With this knowledge it is possible to make precise adjustments to the quantity of product being applied in relation to the size of the target vegetation. The new technologies of precision spraying allow growers to apply pesticides only to the target canopy or fruit, to apply the correct quantity ac...

Genomic Profiling of Patient-Derived Colon Cancer Xenograft Models

Recent evidence suggests that patient derived xenograft (PDX) models can maintain certain pathological and molecular features of the original disease. However, these characterizations are limited to immunohistochemistry or by tissue microarray analysis. We conducted a high-throughput sequencing of primary colon tumor and PDX has not been reported yet. Fresh primary colon cancer tissues that ori...

Next generation patient-derived prostate cancer xenograft models

leading cause of cancer-related death of North American males.1 The disease is at present incurable once it has metastasized, and most deaths from this disease are due to metastases that are highly resistant to current conventional therapies. Prostate cancer is considered a multifocal disease that generally consists of a dominant cancer and one or more concurrent cancers of smaller volume with ...